Senior Molecular Biologist – Protein Complementation Assays

June 16, 2024
Senior Molecular Biologist – Protein Complementation Assays

Job Description:

We are seeking a highly skilled and motivated Senior Molecular Biologist with extensive experience in Protein Complementation Assays (PCA) to join our dynamic research team. The successful candidate will lead projects aimed at developing and optimizing novel PCA-based methods for the study of protein-protein interactions and other macromolecular complexes in live cells. The role requires deep knowledge of molecular cloning, vector design, and assay development, as well as a proven track record of innovative research in biochemistry or molecular biology.

Key Responsibilities:

• Design and execute PCA strategies using various systems (e.g., DHFR, split luciferase, BiFC) to study complex biological interactions.

• Develop and optimize vectors for gene expression and protein tagging in different host systems including mammalian, bacterial, and yeast cells.

• Conduct molecular cloning tasks, including plasmid construction, mutagenesis, and preparation of expression constructs.

• Collaborate with computational biologists to analyze data and integrate findings into broader research projects.

• Lead efforts in troubleshooting and refining experimental protocols.

• Write and contribute to the publication of research findings in peer-reviewed journals.

• Supervise and mentor junior scientists and technicians.

• Maintain up-to-date knowledge of advances in protein complementation assays and related fields.


• PhD in Molecular Biology, Biochemistry, or a related field.

• Postdoctoral experience (3+ years) with a strong focus on protein-protein interactions and PCA technologies.

• Profound understanding of various PCA systems and their applications in biological research.

• Extensive experience in molecular cloning techniques and vector design.

• Demonstrated ability to design and conduct independent research, as evidenced by publication in high-impact journals.

• Experience in supervising and training staff in laboratory settings.

• Excellent communication and organizational skills, with the ability to work collaboratively in a multidisciplinary environment.

Desirable Skills:

• Experience with CRISPR/Cas9 or other genome-editing technologies.

• Familiarity with regulatory guidelines and ethical standards pertaining to genetic and biological research.

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